Urinary Estrogens in Pregnancy
نویسندگان
چکیده
منابع مشابه
Contribution of estriol to total urinary estrogens during pregnancy.
Estriol accounts for an average of 74% of the principal Kober-positive steroids in the urine of 13 women during uncomplicated pregnancies. This proportion is independent of the stage of pregnancy, from 20 weeks until term. The average ratio of estriol to ring-D a#{149}ketols (mainly 16ahydroxyestrone and 16-ketoestradiol-17) is about 5:1 over the same period. In 17 pregnant women with diabetes,...
متن کاملMeasurement of urinary estrogens.
In a commentary on the existingmethodology for the determination of urinary estrogens, data are givenfor normalrangesin nonpregnancy and pregnancyurine aswell as the expectedinterferencesdue to medicationand substancesoccurring in high concentrationsin diseasestates. Becauseof the wide rangeof normal excretionvalues,the point is madethat onlyserialanalysesof a patient’sphysiologic course (e.g.,...
متن کاملRadioimmunoassay of total urinary estrogens.
We describe a radioimmunoassay for total estrogens in urine. Estrogens are extracted by adsorption on XAD-2 resin, eluted with methanol, and acid-hydrolyzed. Estrogens are then determined in a diluted aliquot of the hydrolysate. Within-run coefficients of variation for estriol values between 6.0 and 100 micrograms/L were less than 5%; between-run CV was 19.6% at an estriol concentration of 16.8...
متن کاملUrinary estrogens in pregnancy; improved method for their determination in humans.
NE OF PEE DIFFICULTIES encountered in the determination of urinary estrogens arises from the fact that no procedure so far developed is capable of cleaving the estrogen conjugates quantitatively without destroying any of the free steroids (1). Reporting on a thorough investigation of this subject Van Bruggen (2) stated: “The use of butanol as the solvent and hydrolyzing medium.. . appears to be...
متن کاملSimple assay for urinary estrogens in nonpregnancy.
Shackleton et al. (1), Osawa and Siaunwhite 2), and Beckloff et al. (3) have recently reported simple methods for assay of steroid conjugates in urine by use of columns of Amberlite XAD-2. With Osawa and Slaunwhite’s procedure urinary estrogen conjugates can be assayed with a lower limit of detection in the micromolar range but, as implied by the authors, the assay is useful only for analysis o...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1956
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/2.3.184